Cheers I’ll drink to that bro is a catchphrase and screenshot from The Eric Andre Show.
The image macro depicts Eric raising a bottle of ranch sauce.
Online, it is generally used as a reaction image to show encouragement and sympathy toward anything that was previously said.
The screenshot was taken from the Ranch it up! sketch from the Season 2, Episode 4 of The Eric Andre Show, which first aired on October 24th, 2013.
In the skit, Eric is walking around in an obtrusive outfit asking people absurd questions and offering them ranch sauce.
When someone bursts at him saying “will you just get TF away from me and leave me alone” he responds with “cheers I’ll drink to that bro”.